Edward A. Doisy Department of
Biochemistry and Molecular Biology

Saint Louis University, a Catholic Jesuit institution dedicated to student learning, research, health care, and service, is seeking outstanding applicants for POSTDOCTORAL FELLOW and LABORATORY RESEARCH positions in the Edward A. Doisy Department of Biochemistry and Molecular Biology (http://biochem.slu.edu/). The Department has an outstanding faculty, a long tradition of excellence in research and education and is housed in the state-of-the-art Doisy Research Center completed in 2007. Please see below for more details and the links to apply for these positions.

Saint Louis University is an Affirmative Action, Equal Opportunity Employer, and encourages nominations and applications of women and minorities.



FACULTY POSITIONS

Postdoctoral positions are available in the laboratory of Enrico Di Cera, M.D., Professor and Chair of Biochemistry, to study the structure and mechanism of activation of the thrombin precursors prothrombin and prethrombin-2. Recent Ph.D. graduates with a strong background in enzymology and/or X-ray structural biology are encouraged to apply. Interested candidates should contact Enrico Di Cera directly via e-mail (enrico@slu.edu).

A Postdoctoral/Scientist/Technician position is available in the laboratory of Dr. Susana Gonzalo, Assistant Professor of Biochemistry, beginning immediately. Candidates should have experience in mouse models of tumorigenesis. The project will focus on preclinical studies that test the importance of a novel pathway for diagnosis, prognosis, and customization of breast cancer treatment. Interested candidates should submit a curriculum vitae (which lists at least 2 referees) and a brief letter outlining prior research experience directly to Dr. Gonzalo via e-mail (sgonzalo@slu.edu).

A post-doctoral position is available immediately in the laboratory of Dr. Frances Yap, Assistant Professor of Biochemistry. Successful candidates are expected to have a Ph.D. degree in biochemistry, microbiology, bioinformatics, or related field from an accredited university, and have a deep interest and demonstrated capability in microbial genetics and biochemistry. The research project will focus on the mechanism by which ribosome undergoes translational stalling in response to ribosomal antibiotics and arrest peptides (for more details, see Davis, Gohara and Yap (2014) Sequence selectivity of macrolide-induced translational attenuation. PNAS. 111(34):15379-15384). A variety of experimental methods will be employed, including deep sequencing, molecular genetics and biophysical and biochemical analyses. NIH standards will be used in setting the pay scale. Interested candidates must submit a cover letter, application and current curriculum vitae to Requisiton #20140877

A post-doctoral position is now available in the laboratory of Dr. Alessandro Vindigni,Professor of Biochemistry. Successful candidates are expected to have a Ph.D. degree in life sciences with a special emphasis on biochemistry and molecular cell biology. The laboratory of Dr. Alessandro Vindigni focuses on understanding the mechanisms of replication stress response and the role of ATP-dependent motor proteins in the maintenance of genome integrity. Projects combine cellular, biochemical and structural approaches. Previous experience in the fields of DNA replication and repair is a plus. Applicants should also be highly self-motivated and have a track record of creativity and productivity. NIH standards will be used in setting the pay scale. Interested candidates must submit a cover letter, application and current curriculum vitae to Requisiton #20140866

A post-doctoral position is now available in the laboratory of Dr. Youhna Ayala, Assistant Professor of Biochemistry, to study the role of RNA metabolism in neurodegeneration. A central focus of our work is to uncover the mechanisms linking TDP-43 function and structure to disease. TDP-43 is an RNA-binding protein whose aggregation is recognized as a hallmark of neurodegenerative disorders, specifically amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease) and frontotemporal lobar degeneration. Our work combines biochemical, cellular and molecular biology approaches to investigate the regulation of TDP-43 function, TDP-43-RNA interactions, and protein aggregation. Successful candidates are expected to have a Ph.D. degree in life sciences with a special emphasis on protein expression and protein biochemistry. Previous experience in the fields of RNA processing and nucleic acid-binding proteins is a plus. Preferred candidates will have recently finished their Ph.D. degrees. Applicants should also be highly self-motivated and have a strong track record of creativity and productivity. NIH standards will be used in setting the pay scale. Interested candidates must submit a cover letter, application and current curriculum vitae to Requisiton #20140654

A post-doctoral position is now available in the laboratory of Dr. Dorota Skowyra, Associate Professor of Biochemistry. This post-doctoral fellow will be involved in analysis of peptide mixtures generated by the proteasome from natural protein substrates co-purified from cells, and previous experience with fractionation and analysis of peptide mixtures and familiarity with mass spectrometry is preferred. Successful candidates are expected to have a Ph.D. degree in life sciences. Previous experience with cell fractionation, and purification of proteins and protein complexes would be a plus. NIH standards will be used in setting the pay scale. Interested candidates must submit a cover letter, application and current curriculum vitae to Requisiton #20140658

A post-doctoral position is now available in the laboratory of Dr. Angel Baldan, Professor of Biochemistry. The project involves defining the role of novel genes in the control of lipid metabolism. Experience in one or more of the following areas is required: metabolic diseases, control of lipid metabolism, and cardiovascular and/or liver disease. Successful candidates are expected to have a Ph.D. or equivalent in a relevant field like biochemistry, biology, physiology, pharmacology, molecular biology etc., less than 3 years of post-doctoral experience, and at least one recent publication in the field. Salary is dependent on qualifications and experience. Interested candidates must submit a cover letter with a brief description of research interests, application and current curriculum vitae to Requisiton #20140350



RESEARCH POSITIONS

A Research Assistant position is available beginning immediately. This position will have a central focus around the investigation of uncovering the mechanisms linking TDP-43 function and structure to disease. Interested candidates should submit a cover letter and curriculum vitae to Requisiton #20140964.

A Senior Data Coordinator position is available beginning immediately. Some tasks for this position will be to write computer programs used to analyze genomic research data, collect and analyze data, develop reports, and ensure data integrity. Interested candidates should submit a cover letter, application, and curriculum vitae to Requisiton #20140969.