Ph.D., 2002, University of Barcelona
Research Interests
Our laboratory is interested in sterol homeostasis and in the molecular mechanisms involved in the conversion of macrophages into foam cells. This latter process is particularly relevant in several human pathologies, including atherosclerosis and different pulmonary lipidosis syndromes.
Recent Publications
  • miR-27b inhibits LDLR and ABCA1 expression but does not influence plasma and hepatic lipid levels in mice.
    Goedecke L, Rotllan N, et al. Atherosclerosis. (2015) 243(2):499-509.
  • Akt-mediated FoxO1 inhibition is required for liver regeneration.
    Pauta M, Rotllan N, et al. Hepatology. (2015) [Epub ahead of print].
  • CIDEC/FSP27 is regulated by peroxisome proliferator-activated receptor alpha and plays a critical role in fasting- and diet-induced hepatosteatosis.
    Langhi C, Baldán A. Hepatology. (2015) 61(4):1227-1238.
  • ABCG1 is required for pulmonary B-1 B cell and natural antibody homeostasis.
    Baldán A, Gonen A, et al. J Immunol. (2014) 193(11):5637-5648.
  • Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice.
    Goedeke L, Salerno A, et al. EMBO Mol Med. (2014) 6(9):1133-1141.
  • Perilipin-5 is regulated by statins and controls triglyceride contents in the hepatocyte.
    Langhi C, Marquart TJ, et al. J Hepatol. (2014) 61(2):358-365.
  • Control of very low-denisty lipoprotein secretion by N-ethylmaleimide-sensitive factor and miR-33.
    Allen RM, Marquart TJ, et al. Circ Res. (2014) 115(1):10-22.