Ángel Baldán, Ph.D.
Studies on sterol homeostasis and the molecular mechanisms involved in the conversion of macrophages to foam cells.
Office: DRC, Room 427
Voice: (314) 977-9227
Ph.D., 2002, University of Barcelona
Our laboratory is interested in sterol homeostasis and in the molecular mechanisms involved in the conversion of macrophages into foam cells. This latter process is particularly relevant in several human pathologies, including atherosclerosis and different pulmonary lipidosis syndromes.
- Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration.
Sene A, Khan AA, et al. Cell Metab. (2013) 17(4):549-61.
- MicroRNA-144 regulates hepatic ABCA1 and plasma HDL following activation of the nuclear receptor FXR.
de Aguiar Vallim T, Tarling E, et al. Circ Res. (2013) Mar 21 [Epub ahead of print].
- Anti-miR-22 therapy does not alter the progression of atherosclerosis in low-density lipoprotein receptor-deficient mice.
Marquart TJ, Wu J, et al. Arterioscler Thromb Vasc Biol. (2013) 33(3):455-8.
- Cholesterol efflux analyses using stable isotopes and mass spectrometry.
Brown RJ, Shao F, et al. Anal Biochem. (2012) 433(1):56-64.
- miR-33 controls the expression of biliary transporters, and mediates statin-and diet-induced hepatotoxicity.
Allen RM, Marquart TJ, et al. EMBO Mol Med. (2012) 4(9):882-95.
- Mir-33 regulates cell proliferation and cell cycle progression.
Cirera-Salinas D, Pauta M, et al. Cell Cycle. (2012) 11(5):922-33.