Edward A. Doisy Department of Biochemistry
Education
Ph.D., 1987, California Institute of Technology
Research Interests
Our lab is interested in understanding how two distinct eukaryotic methionine aminopeptidases (MetAPs) function in the amino-terminal processing of eukaryotic proteins and its role in angiogenesis. Recently, the type-2 MetAP was found to be the molecular target for angiogenesis inhibitors, TNP-470 and ovalicin. Angiogenesis is the process of new blood vessel formation. It plays very important roles in both physiological states and a variety of pathological states.
Recent Publications
  • Molecular PINCERs® for biomarker analysis and their potential application in hepatitis C diagnosis.
    Tian L, Wang RE, Chang YH. Antivir Ther. (2012) 17:1437-42.
  • A homogeneous fluorescent sensor for human serum albumin.
    Wang RE, Tian L, Chang YH. J Pharm Biomed Anal. (2012) 63:165-9.
  • A homogeneous fluorescent assay for cAMP-phosphodiesterase enzyme activity.
    Tian L, Wang RE, Fei Y, Chang YH. J Biomol Screen. (2012) 17(3):409-14.