Yie-Hwa Chang, Ph.D.
Understanding how two distinct eukaryotic methionine aminopeptidases (MetAPs) function in the amino terminal processing of eukaryotic proteins and its role in angiogenesis.
Office: DRC, Room 515
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Ph.D., 1987, California Institute of Technology
Our lab is interested in understanding how two distinct eukaryotic methionine aminopeptidases (MetAPs) function in the amino-terminal processing of eukaryotic proteins and its role in angiogenesis. Recently, the type-2 MetAP was found to be the molecular target for angiogenesis inhibitors, TNP-470 and ovalicin. Angiogenesis is the process of new blood vessel formation. It plays very important roles in both physiological states and a variety of pathological states.
- Molecular PINCERs® for biomarker analysis and their potential application in hepatitis C diagnosis.
Tian L, Wang RE, Chang YH. Antivir Ther. (2012) 17:1437-42.
- A homogeneous fluorescent sensor for human serum albumin.
Wang RE, Tian L, Chang YH. J Pharm Biomed Anal. (2012) 63:165-9.
- A homogeneous fluorescent assay for cAMP-phosphodiesterase enzyme activity.
Tian L, Wang RE, Fei Y, Chang YH. J Biomol Screen. (2012) 17(3):409-14.