Yie-Hwa Chang, Ph.D.
Understanding how two distinct eukaryotic methionine aminopeptidases (MetAPs) function in the amino terminal processing of eukaryotic proteins and its role in angiogenesis.
Office: DRC, Room 515
Voice: (314) 977-9263
Ph.D., 1987, California Institute of Technology
Our lab is interested in understanding how two distinct eukaryotic methionine aminopeptidases (MetAPs) function in the amino-terminal processing of eukaryotic proteins and its role in angiogenesis. Recently, the type-2 MetAP was found to be the molecular target for angiogenesis inhibitors, TNP-470 and ovalicin. Angiogenesis is the process of new blood vessel formation. It plays very important roles in both physiological states and a variety of pathological states.
- Protein O-GlcNAcylation.
4. Tian L, Simmons G, Chang YH. JSM Biochem Mol Biol. (2013) 1(1):1005-7.
- A pilot study of pepsin in tracheal and oral secretions.
Challom M, Tricomi S, et al. Am J Crit Care. (2013) 22(5):408-11.
- Characterization and quantization of hepcidin from human and mouse serum and secretion medium from human cell line Hu.7 by MALDI mass spectrometry.
Hassan MI, Waheed A, et al. J Prot Proteom. (2012) 3(3):177-84.
- Molecular PINCERs® for biomarker analysis and their potential application in hepatitis C diagnosis.
Tian L, Wang RE, Chang YH. Antivir Ther. (2012) 17:1437-42.
- A homogeneous fluorescent sensor for human serum albumin.
Wang RE, Tian L, Chang YH. J Pharm Biomed Anal. (2012) 63:165-9.
- A homogeneous fluorescent assay for cAMP-phosphodiesterase enzyme activity.
Tian L, Wang RE, Fei Y, Chang YH. J Biomol Screen. (2012) 17(3):409-14.