Thomas Yoonsang Cho, Ph.D.
Structural and chemical biology of ligands and receptors in inflammation and cancer.
Office: DRC, Room 503
Phone: (314) 977-9284
Ph.D., 2005, Texas A&M University
Immune cells have direct and indirect interaction with other cells. The indirect interactions include the secretion of small protein ligands such as cytokines, chemokines, and growth factors for binding and activating receptors. However, the molecular details of the binding mechanisms are still largely unknown. We are interested in understanding how these protein ligands interact with different receptors. We subsequently want to translate this information to develop small molecules modulating the protein ligands in a receptor-specific manner with therapeutic effects against inflammatory diseases and cancer. We use a variety of techniques, including biochemical and biophysical methods such as X-ray crystallography and NMR, high-throughput screening, virtual docking, biosensor-based label-free cellular assay system, as well as animal models of human diseases.
- Structural basis for decreased induction of class 1B P13-kinases expression by MIF inhibitors.
Singh AK, Pantouris G, et al. J Cell Mol Med. (2016) Sept 13 [Epub ahead of print].
- New insights into mechanisms and functinos of chemokine (C-X-C motif) receptor 4 heteromerization in vascular smooth muscle.
Evans AE, Tripathi A, et al. Int J Mol Sci. (2016) 17(5) pii:E971.
- Optogenetic control of chemokine receptor signal and T-cell migration.
Xu Y, Hyun YM, et al. Proc Natl Acad Sci USA. (2014) 111(17):6371-6376.