Carmine Coscia, Ph.D.
Opioid receptors and the effects of opioids on brain development.
Office: DRC, Room 411
Voice: (314) 977-9254
Ph.D., 1962, Fordham University
Opioid receptors are the targets of narcotics such as morphine and heroin. The long-range goal of our research is focused on how opioids affect brain development.
- Acute and chronic mu opioids differentially regulate thrombospondins 1 and 2 isoforms in astrocytes.
Phamduong E, Rathore MK, et al. ACS Chem. Neurosci. (2013) Dec 5 [Epub ahead of print].
- Morphine modulation of thrombospondin levels in astocytes and its implications for neurite outgrowth and synapse formation.
Ikeda H, Myatake M, et al. J Biol Chem. (2010) 285(49):38415-27.
- Mu and kappa opioids modulate mouse embryonic stem cell-derived neural progenitor differentiation via MAP kinases.
Hahn JW, Jagwani S, Kim E, et al. J Neurochem. (2010) 112(6):1431-41.