Dale Dorsett, Ph.D.
Chromosome structure control of gene expression during development using Drosophila molecular genetics and elucidation of the molecular mechanisms of Cornelia de Lange syndrome.
Office: DRC, Room 423
Voice: (314) 977-9218
Ph.D., 1980, University of Tennessee Oakridge National Laboratory
We use Drosophila molecular genetics to understand how chromosome structure controls gene expression during development. Our studies have shed light on the molecular mechanisms of Cornelia de Lange syndrome, which causes diverse developmental deficits in humans.
li>Wap1 antagonizes cohesin binding and promotes Polycomb-group silencing in Drosophila.
Cunningham MD, Gause M, et al. Development. (2012) 139(22):4172-9.
- The Drosophila MI-2 chromatin-remodeling factor regulates higher-order chromatin structure and cohesin dynamics in vivo.
Fasulo B, Deuring R, et al. PLoS Genet. (2012) 8(8):e1002878.
- The ancient and evolving roles of cohesin in gene expression and DNA repair.
Dorsett D, Strom L. Curr Biol. (2012) 22(7):R240-R250.
- Cohesin selectively binds and regulates genes with paused RNA polymerase.
Fay A, Misulovin Z, et al. Curr Biol. (2011) 21(19):1624-1634.
- Cohesin: genomic insights into controlling gene transcription and development.
Dorsett D. Curr Opin Gent Dev. (2011) 21(2):199-206.