Dale Dorsett, Ph.D.
Chromosome structure control of gene expression during development using Drosophila molecular genetics and elucidation of the molecular mechanisms of Cornelia de Lange syndrome.
Office: DRC, Room 423
Voice: (314) 977-9218
Ph.D., 1980, University of Tennessee Oakridge National Laboratory
We use Drosophila molecular genetics to understand how chromosome structure controls gene expression during development. Our studies have shed light on the molecular mechanisms of Cornelia de Lange syndrome, which causes diverse developmental deficits in humans.
- HCoDES reveals chromosomal DNA end structures with single-nucleotide resolution.
Dorsett Y, Zhou Y, et al. Mol Cell. (2014) Nov 25 [Epub ahead of print].
- Checks and balances between cohesion and polycomb in gene silencing and transcription.
Dorsett D, Kassis JA. Curr Biol. (2014) 24(11):R535-R539.
- Sall1 balances self-renewal and differentiation of renal progenitor cells.
Basta JM, Robbins L, et al. Development. (2014) 141(5):1047-1058.
- Cornelia de Lang syndrome: Further delineation of phenotype, cohesion biology and educational focus, 5th Biennial Scientific and Educational Symposium abstracts.
Kline AD, Calof AL, et al. Am J Med Genet A. (2014) 164A(6):1384-1393.
- What fruit flies can tell us about human birth defects.
Dorsett D. Mo Med. (2013) 110(4):309-313.
- The Drosophila enhancer of split gene complex: Architecture and coordinate regulation by Notch, Cohesion, and Polycomb group proteins.
Schaaf CA, Misulovin Z, et al. G3 (Bethesda). (2013) 3(10):1785-1794.
- Cohesin and polycomb proteins functionally interact to control transcription at silenced and active genes.
Schaaf CA, Misulovin Z, et al. PLoS Genet. (2013) 9(6):e1003560.
- Genome-wide control of RNA polymerase II activity by cohesion.
Schaaf CA, Kwak A, et al. PLoS Genet. (2013) 9(3):e1003382.
- Cohesin at active genes: A unifying theme for cohesion and gene expression from model organisms to humans.
Dorsett D, Merkenschlager M. Curr Opin Cell Biol. (2013) 25(3):327-333.