Edward A. Doisy Department of Biochemistry
Education
Ph.D., 1982, University of North Carolina, Chapel Hill
Research Interests
Research in my lab concerns four aspects of transcriptional regulation: histone biotinylation and gene expression; transcriptional activation and chromatin remodeling; RNA polymerase elongation factors and gene regulation; and heterochromatin and gene regulation. We use the fruit fly, Drosophila melanogaster, as a model to study mechanisms of gene activation and gene silencing.
Recent Publications
  • Structural biology of the chromo domain: Form and function.
    Eissenberg JC. Gene. (2012), Jan 18 [Epub ahead of print].
  • The little elongation complex (LEC) regulates small nuclear RNA transcription.
    Smith ER, Lin C, Garrett AS, Thornton J, Mohaghegh N, Jackson J, Saraf A, Swanson SK, Seidel C, Florens L, Washburn MP, Eissenberg JC, Shilatifard A. Mol Cell. (2011), 44:954-965.
  • The role of MOF in the ionizing radiation response is conserved in Drosophila melanogaster.
    Bhadra MP, Horikoshi N, Pushpavallipvalli SNCVL, Sarkar A, Bag I, Krishan A, Lucchesi JC, Kumar R, Yang Q, Pandita RK, Singh M, Bhadra U, Eissenberg JC, Pandita TK. Chromosoma. (2012) 121(1):79-90.
  • Drosophila GGA-model: An ultimate gateway to GGA analysis.
    Eissenberg JC, Ilvarsonn AM, Sly WS, Waheed A, Krzyzanek V, Pohlmann R, Waschkau D, Kretzchmar D, Dennes AC. Traffic. (2011) 12:1821-1838.
  • The COMPASS family of H3K4 methylases in Drosophila.
    Mohan M, Herz H-M, Smith ER, Zhang Y, Jackson J, Washburn MP, Florens L, Eissenberg JC, Shilatifard A. Mol Cell Biol. (2011) 31:4310-4318.
  • Histone H3 lysine 4 (H3K4) methylation in development and differentiation.
    Eissenberg JC, Shilatifard A. Dev Biol. (2010) 339:240-249.