Susana Gonzalo, Ph.D.
Nuclear architecture, chromatin structure, and genomic instability in aging and cancer.
Office: DRC, Room 327
Voice: (314) 977-9244
Ph.D., Washington University School of Medicine
Alterations in the DNA damage response pathway, DNA repair mechanisms, and telomere biology are among the leading causes of genomic instability in aging and cancer. Our long term goal is to identify novel molecular pathways contributing to genomic instability, which can be used as therapeutic targets. We have focused on understanding how alterations in nuclear structural proteins –lamins- and chromatin structure -epigenetic changes- impact on DNA repair and telomere biology. Our studies revealed new pathways important in diseases such as laminopathies and cancer that are being tested as potential biomarkers for diagnosis, prognosis, and customization of treatment.
- Differences in 53BP1 and BRCA1 regulation between cycling and non-cycling cells.
Croke M, Neumann MA, et al. Cell Cycle. (2013) 12(23) [Epub ahead of print].
- Novel roles of 1α,25(OH)2D3 on DNA repair provide new strategies for breast cancer treatment.
Gonzalo S. J Steroid Biochem Mol Biol. (2013) Sept 27 [Epub ahead of print].
- The two faces of DNA repair: disease and therapy.
Vindigni A, Gonzalo S. Mo Med. (2013) 110(4):314-319.
- BRCA1 loss activates cathepsin L-mediated degradation of 53BP1 in breast cancer cells.
Grotsky DA, Gonzalez-Suarez I, et al. J Cell Biol. (2013) 200(2):187-202.