Tomasz Heyduk, Ph.D.
Professor and Associate Director for Basic Sciences, Cancer Center
Mechanisms of transcription regulation and development of novel sensors for biomolecule detection and imaging.
Office: DRC, Room 425
Phone: (314) 977-9238
Ph.D., 1986, Technical University of Wroclaw, Poland
Our lab has two major research interests: mechanisms of transcription regulation and development of novel sensors for biomolecule detection and imaging. Our interest in transcription regulation is to understand the mechanism of transcription initiation by bacterial and archaeal RNA polymerases. Our primary focus in sensor research is to develop robust highly specific and sensitive molecular sensors that could be utilized in research, medical diagnosis and pathogen detection.
- Real-time observation of back tracking by bacterial RNA polymerase.
Lass-Napiorkowska A and Heyduk T. Biochemistry. (2016) Jan 8 [Ebup ahead of print]. PubMed PMID: 26745324
- Next generation sequencing-based analysis of RNA polymerase functions.
Heyduk T and Heyduk E. Methods. (2015) 86:37-44. PubMed PMID: 25937393
- Ribosome display enhanced by next generation sequencing: A tool to identify antibody-specific peptide ligands.
Heyduk T and Heyduk E. Anal Biochem. (2014) 464:73-82. PubMed PMID: 25058925
- Kinetics of promoter escape by bacterial RNA polymerase: effects of promoter contacts and transcription bubble collapse.
Ko J, Heyduk T. Biochem J. (2014) 463(1):135-144. PubMed PMID: 24995916
- Next generation sequencing-based parallel analysis of melting kinetics of 4096 variants of a bacterial promoter.
Heyduk E, Heyduk T. Biochemistry. (2014) 53(2):282-292. PubMed PMID: 24359527