Tomasz Heyduk, Ph.D.
Professor and Associate Director for Basic Sciences, Cancer Center
Mechanisms of transcription regulation and development of novel sensors for biomolecule detection and imaging.
Office: DRC, Room 425
Voice: (314) 977-9238
Ph.D., 1986, Technical University of Wroclaw, Poland
Our lab has two major research interests: mechanisms of transcription regulation and development of novel sensors for biomolecule detection and imaging. Our interest in transcription regulation is to understand the mechanism of transcription initiation by bacterial and archaeal RNA polymerases. Our primary focus in sensor research is to develop robust highly specific and sensitive molecular sensors that could be utilized in research, medical diagnosis and pathogen detection.
- Next generation sequencing-based parallel analysis of melting kinetics of 4096 variants of a bacterial promoter.
Heyduk E, Heyduk T. Biochemistry. (2014) Jan 7 [Epub ahead of print]. PubMed PMID: 24359527
- Crystal structure of prothrombin reveals conformational flexibility and mechanism of activation.
Pozzi N, Chen Z, et al. J Biol Chem. (2013) 288(31):22734-22744. PubMed PMID: 2377508
- Detection methodology based on target molecule-induced sequence-specific binding to a single-stranded oligonucleotide.
Lass-Napiorkowska A, Heyduk E, et al. Anal Chem. (2012) 84(7):3382-3389. PubMed PMID: 22401560
- Promoter spacer DNA plays an active role in integrating the functional consequences of RNA polymerase contacts with -10 and -35 promoter elements.
Sztiller-Sikorska M, Heyduk E, and Heyduk T. Biophys Chem. (2011) 159(1):73-81. PubMed PMID: 21621902