Tomasz Heyduk, Ph.D.
Professor and Associate Director for Basic Sciences, Cancer Center
Mechanisms of transcription regulation and development of novel sensors for biomolecule detection and imaging.
Office: DRC, Room 425
Voice: (314) 977-9238
Ph.D., 1986, Technical University of Wroclaw, Poland
Our lab has two major research interests: mechanisms of transcription regulation and development of novel sensors for biomolecule detection and imaging. Our interest in transcription regulation is to understand the mechanism of transcription initiation by bacterial and archaeal RNA polymerases. Our primary focus in sensor research is to develop robust highly specific and sensitive molecular sensors that could be utilized in research, medical diagnosis and pathogen detection.
- Kinetics of promoter escape by bacterial RNA polymerase: effects of promoter contacts and transcription bubble collapse.
Ko J, Heyduk T. Biochem J. (2014) Jul 4 [Epub ahead of print]. PubMed PMID: 24995916
- Next generation sequencing-based parallel analysis of melting kinetics of 4096 variants of a bacterial promoter.
Heyduk E, Heyduk T. Biochemistry. (2014) 53(2):282-292. PubMed PMID: 24359527
- Crystal structure of prothrombin reveals conformational flexibility and mechanism of activation.
Pozzi N, Chen Z, et al. J Biol Chem. (2013) 288(31):22734-22744. PubMed PMID: 2377508