Jon Jacobsen, Ph.D.
Director of Chemistry
Center for World Health and Medicine
Research on neglected diseases and diseases of poverty, including childrenŐs diarrhea, malaria, tuberculosis and a number of filarial infections such as River Blindness, African sleeping sickness, and Chagas disease.
Office: DRC, Room 317
Voice: (314) 977-5139
Ph.D., University of California, Irvine
Since joining SLU and the Center for World Health and Medicine in 2010 my research interests have focused on neglected diseases and diseases of poverty. These include childrenŐs diarrhea, malaria, tuberculosis and a number of filarial infections including River Blindness, African sleeping sickness, and Chagas disease. Some of the mechanisms being pursued for these disorders are inhibitors of Hsp90, NEP, and MetAP. Here my major focus as a chemist will to help repurpose advanced clinical agents towards these diseases or carry out focused medicinal chemistry and structure-based drug design approaches based on advanced leads to find compounds that may offer a viable treatment.
- Evaluation of aminohydantoins as a novel class of antimalarial agents.
Meyers MJ, Tortorella MD, et al. ACS Med Chem Lett. (2013) 5(1):89-93.
- The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes
Tavis JE, Cheng X, et al. PLoS Pathog. (2013) 9(1):e1003125.