Sergey Korolev, Ph.D.
Structure-functional studies of DNA recombination, replication and repair proteins.
Office: DRC, Room 513
Phone: (314) 977-9261
Ph.D., 1993 Engelhardt Institute of Biochemistry and Molecular Biology, Moscow, Russian Academy of Sciences
Our lab studies the mechanism of protein function at the atomic resolution level utilizing X-ray crystallography and biochemical approaches. The main focus is recombination mediator proteins (RMPs), which are essential for genome stability and DNA repair in all organisms.
- RecO protein initiates DNA recombination and strand annealing through two alternative DNA binding mechanisms.
Ryzhikov M, Gupta R, et al. J Biol Chem. (2014) 289(42):28846-28855.
- Rous sarcoma virus synaptic complex capable of concerted integration is kinetically trapped by human immunodeficiency virus integrase strand transfer inhibitors.
Pandey KK, Bera S, et al. J Biol Chem. (2014) 289(28):19648-58.