Nicola Pozzi, Ph.D.
Molecular mechanisms of thrombosis and immunothrombosis.
Office: DRC, Room 511
Phone: (314) 977-9257
Ph.D., 2010, University of Padua, Italy.
In our laboratory, we strive to understand the pathophysiological mechanisms that lead to thrombosis and immunothrombosis, an innate immune response that links coagulation to the recognition, containment and destruction of microbial pathogens. To achieve our goals, we apply a unique combination of biochemistry, protein engineering, X-ray crystallography, single molecule fluorescence biophysics (smFRET and FCS) and surface plasmon resonance (SPR).
- Molecular mapping of α-thrombin (& alpha;T)/β2-glycoprotein I (β2GpI) interaction reveals how β2GpI affects αT functions.
Acquasaliente L, Peterle D, Tescari S, Pozzi N, Pengo V, De Filippis V. Biochem J. (2016) 473(24):4629-4650.
- Costimulatory effects of an immunodominant parasite antigen paradoxically prevent induction of optimal CD8 T Cell protective immunity.
Eickhoff CS, Zhang X, Vasconcelos JR, Motz RG, Sullivan NL, O'Shea K, Pozzi N, Gohara DW, Blase JR, Di Cera E, Hoft DF. PLoS Pathos. (2016) 12(9):e1005896.
- Structural architecture of prothrombin in solution revealed by single molecule spectroscopy.
Pozzi N, Bystranowska D, Zuo X, Di Cera E. J Biol Chem. (2016) 291(35):18107-18116.
- Dual effect of histone H4 on prothrombin activation.
Pozzi N, Di Cera E. J Thromb Haemost. (2016) 14(9):1814-1818.
- Loop electrostatics asymmetry modulates the preexisting conformational equilibrium in thrombin.
Pozzi N, Zerbetto M, Acquasaliente L, Tescari S, Frezzato D, Polimeno A, Gohara DW, Di Cera E, De Filippis V. Biochemistry. (2016) 55(28):3984-3994.
- How the linker connecting the two Kringles influences activation and conformational plasticity of prothrombin.
Pozzi N, Chen Z, Di Cera E. J Biol Chem. (2016) 291(12):6071-82.