Education
Ph.D., 1989, Boston University
Research Interests
Our research is primarily focused on understanding the mechanism by which coagulation proteases interact with their target cofactors, substrates, and inhibitors, and how heparin enhances the inhibitory function of antithrombin in the regulation of the proteolytic activities of these proteases. Another project in the lab focuses on understanding the mechanism by which coagulation proteases interact with endothelial cell surface receptors to elicit diverse intracellular signaling responses. We employ biophysical, biochemical, and molecular biological approaches to study these questions.
Recent Publications
  • Expression and characterization of Gly-317 variants of Factor IX causing variable bleeding in Hemophilia B patients.
    Lu Q, Yang L, et al. Biochemistry. (2015) 54(24):3814-3821.
  • Inorganic polyphosphate elicits pro-inflammatory responses through activation of the mammalian target of rapamycin complexes 1 and 2 in vascular endothelial cells.
    Hassanian SM, Dinarvand P, et al. J Thromb Haemost. (2015) 13(5):860-871.
  • Protein C Thr315Ala variant results in gain-of-function but manifests as type II deficiency in diagnostic assays.
    Ding Q, Yang L, et al. Blood. (2015) 125(15):2428-2434.
  • Intraperitoneal administration of activated protein C prevents post surgical adhesion band formation.
    Dinarvand P, Hassanian SM, et al. Blood. (2015) 125(8):1339-1348.
  • Conformational activation of antithrombin by heparin involves an altered exosite interaction with protease.
    Izaguirre G, Aguila S, et al. J Biol Chem. (2014) 289(49):34049-34064.
  • Antithrombin up-regulates AMP-activated protein kinase signalling during myocardial ischaemia/reperfusion injury.
    Ma Y, Wang J, et al. Thromb Haemost. (2014) 113(2):338-349.
  • Molecular basis of the clotting defect in a bleeding patient missing the Asp-185 codon in the factor X gene.
    Lu Q, Yang L, et al. Thromb Res. (2014) 134(5):1103-1109.
  • Protease-activated receptor signalling by coagulation proteases in endothelial cells.
    Rezaie AR. Thromb Haemost. (2014) 112(5):876-882.
  • Characterization of the protein Z-dependent protease inhibitor interactive-sites of protein Z.
    Qureshi SH, Lu Q, et al. Biochim Biophys Acta. (2014) 1844(9):1631-1637.
  • Engineering D-helix of antithrombin in alpha-1-proteinase inhibitor confers anti-inflammatory properties on the chimeric serpin.
    Yang L, Dinarvand P, et al. Thromb Haemost. (2014) 112(1):164-75.
  • Adenosine regulates the pro inflammatory signaling function of thrombin in endothelial cells.
    Hassanian SM, Dinarvand P, Rezaie AR. J Cell Physiol. (2014) 229(9):1292-300.
  • Thrombomodulin modulates cell migration in human melanoma cell lines.
    de Oliveira Ada S, Yang L, et al. Melanoma Res. (2014) 24(1):11-9.