Education
Ph.D., 1989, Boston University
Research Interests
Our research is primarily focused on understanding the mechanism by which coagulation proteases interact with their target cofactors, substrates, and inhibitors, and how heparin enhances the inhibitory function of antithrombin in the regulation of the proteolytic activities of these proteases. Another project in the lab focuses on understanding the mechanism by which coagulation proteases interact with endothelial cell surface receptors to elicit diverse intracellular signaling responses. We employ biophysical, biochemical, and molecular biological approaches to study these questions.
Recent Publications
  • Occupancy of human EPCR by protein C induces β-arrestin-2 biased PAR1 signaling by both APC and thrombin..
    Roy RV, Ardeshirglajimi A, et al. Blood. (2016) Aug 25 [Epub ahead of print].
  • Activated protein C protects against renal ischaemia/reperfusion injury, independent of its anticoagulant properties.
    Latinist L, Jansen MP, et al. Thromb Haemost. (2016) 116(1):124-133.
  • Correction to phosphatidylserine-induced factor Xa dimerization and binding to factor Va are competing processes in solution.
    Majumder R, Koklic T, et al. Biochemistry. (2016) 55(10):1554.
  • Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice.
    Liang HP, Kerschen EJ, et al. Blood. (2015) 126(21):2415-2423.
  • Expression and characterization of Gly-317 variants of Factor IX causing variable bleeding in Hemophilia B patients.
    Lu Q, Yang L, et al. Biochemistry. (2015) 54(24):3814-3821.
  • Inorganic polyphosphate elicits pro-inflammatory responses through activation of the mammalian target of rapamycin complexes 1 and 2 in vascular endothelial cells.
    Hassanian SM, Dinarvand P, et al. J Thromb Haemost. (2015) 13(5):860-871.
  • Protein C Thr315Ala variant results in gain-of-function but manifests as type II deficiency in diagnostic assays.
    Ding Q, Yang L, et al. Blood. (2015) 125(15):2428-2434.
  • Intraperitoneal administration of activated protein C prevents post surgical adhesion band formation.
    Dinarvand P, Hassanian SM, et al. Blood. (2015) 125(8):1339-1348.