Alessandro Vindigni, Ph.D.
Studies on DNA replication stress, genome stability, and human disease.
Office: DRC, Room 505
Phone: (314) 977-9217
Ph.D., 1995, University of Padua, Italy
My group uses a combination of cellular, biochemical, and structural approaches to study the enzymatic activity and function of the human RecQ helicases, a family of enzymes that play a key role in the maintenance of genome integrity. RecQ helicases have attracted considerable interest in recent years, not only because of their role in the maintenance of chromosome stability, but also for their connection to disorders associated with cancer predisposition and premature aging.
- Fourier transform infrared microspectroscopy reveals biochemical changes associated with glioma stem cell differentiation.
Kenig S, Bedolla DE, et al. Biophys Chem. (2015) 207:90-96.
- Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: Insights from DNA complex structures.
Pike ACW, Gomathinayagam S, et al. Proc Natl Acad Sci USA. (2015) 112(14):4286-4291.
- Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells.
Zellweger R, Dalcher D, et al. J Cell Biol. (2015) 208(5):563-579.
- DNA2 drives processing and restart of reversed replication forks in human cells.
Thangavel S, Berti M, et al. J Cell Biol. (2015) 208(5):545-562.
- Identification of RECQ1-regulated transcriptome uncovers a role of RECQ1 in regulation of cancer cell migration and invasion.
Li XL, Lu X, et al. Cell Cycle. (2014) 13(15):2431-2445.