M.D., Ph.D., 1992, Shanghai Second Medical University, China
Research Interests
We are interested in the molecular and genetic mechanisms of cholesterol homeostasis and the pathophysiology of cholesterol-related diseases. Our current research focuses on the pathophysiology of cholesterol gallstone disease and genetic analysis of gallstone (Lith) genes, the molecular physiology and genetics of the intestinal cholesterol and fatty acid absorption, the biochemistry of bile formation, and the physical-chemistry of cholesterol crystallization in bile. Also, our research is directed principally at a specific area that appears to be fundamental to understanding nonalcoholic fatty liver disease, insulin resistance, and the metabolic syndrome.
Recent Publications
  • Therapeutic reflections in cholesterol homeostasis and gallstone disease: a review.
    Di Ciaula A, Wang DQ, et al. Curr Med Chem. (2014) 21(12):1435-1447.
  • Pathogenic role of oxidative and nitrosative stress in primary biliary cirrhosis.
    Grattagliano I, Calamita G, et al. World J Gastroenterol. (2014) 20(19):5746-5759.
  • A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes..
    Grattagliano I, Diogo CV, et al. World J Gastroenterol. (2013) 19(20):3007-3017.
  • New insights into the molecular mechanism of intestinal fatty acid absorption.
    Wang TY, Liu M, et al. Eur J coin Invest. (2013) 43(11):1203-1223.
  • Steatosis in the liver.
    Wang DQ, Portincasa P, et al. Compr Physiol. (2013) 3(4):1493-1532.
  • Current views on genetics and epigenetics of cholesterol gallstone disease.
    Di Ciaula A, Wang DQ, et al. Cholesterol. (2013) 2013:298421.
  • Prevention of cholesterol gallstones by inhibiting hepatic biosynthesis and intestinal absorption of cholesterol.
    Wang HH, Portincasa P, et al. Eur J clin Invest. (2013) 43(4):413-426.