Frances Yap, Ph.D.
Mechanism of translational regulation and the molecular responses of ribosome tunnel to different antibiotics and nascent polypeptides.
Office: DRC, Room 403
Phone: (314) 977-9241
Ph.D., 2006, University of Wisconsin-Madison
Few biochemical reactions are as critical for life as translation. We are interested in understanding the functional consequences of arrested translation (or "ribosome stalling") for controlling gene expression and protein biogenesis using genome-wide proteomics, next-generation sequencing, bacterial genetics and biochemistry. We also aim to investigate the selectivity and resistance properties of antibiotics that target the ribosome tunnel. This work will help in the development of more effective antimicrobial drugs.
- The expression of antibiotic resistance methyltransferase correlates with mRNA stability independently of ribosome stalling.
Dzyubak E, Yap MF. Antimicrob Agents Chemother. (2016) Sept 19 [Epub ahead of print].
- Ribosome hibernation factor promotes Staphylococcal survival and differentially represses translation.
Basu A, and Yap, MNF. Nucleic Acids Res. (2016) 44(10):4881-4893.
- Sequence selectivity of macrolide-induced translational attenuation.
Davis AR, Gohara DW, Yap MN. Proc Natl Acad Sci USA. (2014) 111(43):15379-15384.