Frances Yap, Ph.D.
Mechanism of translational regulation and the molecular responses of ribosome tunnel to different antibiotics and nascent polypeptides.
Office: DRC, Room 403
Voice: (314) 977-9241
Ph.D., 2006, University of Wisconsin-Madison
Few biochemical reactions are as critical for life as translation. We are interested in understanding the functional consequences of arrested translation (or "ribosome stalling") for controlling gene expression and protein biogenesis using genome-wide proteomics, next-generation sequencing, bacterial genetics and biochemistry. We also aim to investigate the selectivity and resistance properties of antibiotics that target the ribosome tunnel. This work will help in the development of more effective antimicrobial drugs.
- Mutations in the ribosomal protein L22 selectively suppress the expression of a secreted bacterial virulence factor.
Yap MN and Bernstein HD. J Bacteriol. (2013) Apr 26 [Epub ahead of print].
- The translational regulatory function of SecM requires a novel mode of membrane targeting.
Yap MN and Bernstein HD. Mol Microbiol. (2011) 81(2):540-53.
- Genome sequence of the plant-pathogenic bacterium Dickeya dadantii 3937.
Glasner JD, Yang CH, et al. J Bacteriol. (2011) 193(8):2076-7.
- The plasticity of a translation arrest motif yields insights into nascent polypeptide recognition inside the ribosome tunnel.
Yap MN and Berstein HD. Mol Cell. (2009) 34(2):201-11.