Frances Yap, Ph.D.
Associate Professor

Mechanism of translational regulation and the molecular responses of ribosome tunnel to different antibiotics and nascent polypeptides.

Office: DRC 403
Voice: (314) 977-9241

Research Interests

Few biochemical reactions are as critical for life as translation. We are interested in understanding the functional consequences of arrested translation (or "ribosome stalling") for controlling gene expression and protein biogenesis using genome-wide proteomics, next-generation sequencing, bacterial genetics and biochemistry. We also aim to investigate the selectivity and resistance properties of antibiotics that target the ribosome tunnel. This work will help in the development of more effective antimicrobial drugs.

Recent Publications

The Expression of Antibiotic Resistance Methyltransferase Correlates with mRNA Stability Independently of Ribosome Stalling

Ribosome hibernation factor promotes Staphylococcal survival and differentially represses translation
Basu A and Yap MN

Sequence selectivity of macrolide-induced translational attenuation
Davis AR, Gohara DW and Yap MN

The double life of antibiotics

Mutations in the Escherichia coli ribosomal protein L22 selectively suppress the expression of a secreted bacterial virulence factor
Yap MN and Bernstein HD

Department of Biochemistry and Molecular Biology