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Frances Yap, Ph.D.
Associate Professor

Mechanism of translational regulation and the molecular responses of ribosome tunnel to different antibiotics and nascent polypeptides.

Office: DRC 403
Voice: (314) 977-9241

Research Interests

Few biochemical reactions are as critical for life as translation. We are interested in understanding the functional consequences of arrested translation (or "ribosome stalling") for controlling gene expression and protein biogenesis using genome-wide proteomics, next-generation sequencing, bacterial genetics and biochemistry. We also aim to investigate the selectivity and resistance properties of antibiotics that target the ribosome tunnel. This work will help in the development of more effective antimicrobial drugs.

Recent Publications

Department of Biochemistry and Molecular Biology
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