A shared-use facility that supports expression, purification, and analysis of research proteins by providing an array of instrumentation and consultation on strategies for protein production from small to large scale.
The Facility is managed by Dave Wood, Ph.D. (314-977-9220; firstname.lastname@example.org).
For a complete description of all available services, please see the Protein Core website.
A full-service facility that provides investigators with a variety of options for whole genome analysis via microarrays, high-throughput screening, immunoprecipitation, and sequencing strategies.
The Facility is managed by Dale Dorsett, Ph.D. (314-977-9218; email@example.com) and Audrey Watson (314-977-9252; firstname.lastname@example.org).
A state-of-the-art X-ray facility is available to researchers in the department for the collection of high-resolution data on macromolecular samples. The facility has a 0.8 kW MM007 Rigaku generator with VHF optics interfaced to an R-Axis IV++ imaging plate system and a 1.2 kW MM007HF Rigaku generator with VHF optics double ported with two R-Axis IV++ imaging plate systems. A Phoenix robotic instrumentation from Art Robbins Instruments is available for the preparation, screening and imaging of crystals.
The Facility is managed by Sergey Korolev, Ph.D. (314-977-9261; email@example.com).
The Department of Biochemistry and Molecular Biology maintains a wide variety of computing resources. These range from network and backup services to state-of-the-art high performance computing.
The most recent addition to the department is the Gemini Computing Cluster, a state-of-the-art, high performance computing cluster, leveraging modern technologies such as GPU computing capabilities. You can find out more information on the Gemini website.
Computational publications resulting from use of the Gemini Computing Cluster for some component of the work:
Funding resulting from use of the Gemini Computing Cluster for some component of the work:
The Bioinformatics Facility offers complete analysis of high-throughput expression data, including gene ontology enrichment analysis. We also offer next-generation genomic sequence assembly and variant analysis. We maintain an in-house MASCOT database for peptide mass searches, NCBI BLAST for custom database searching, and HMMer for protein domain searches. Custom script development is available for automation of protein and DNA sequence analysis. We have access to a state-of-the-art high performance-computing cluster maintained by the Biochemistry HPC core.
The Facility is managed by Maureen Donlin, Ph.D. (314-977-8858; firstname.lastname@example.org).
Recent publications from data analyzed by the core: